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Clinical trials and research at SWOG Cancer Research Network

• 31Clinical trials
• 10Countries

Newest trials

All recruiting trials (31)

• Shorter radiation course vs standard course for soft tissue sarcoma of the limb/trunk

  This trial tests whether a 5-day, ultrahypofractionated radiation therapy approach works as well as the standard 25-day course for soft tissue sarcoma that can be surgically removed.

  Recruiting at 67 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 66 other locations · NCT07615049

• Adding Surgery and Radiation to Standard Therapy for HER2+ Stage IV Breast Cancer

  This study tests whether adding surgery, radiation, and targeted ablative radiotherapy to the usualHER2-directed systemic therapy helps patients with newly diagnosed oligometastatic HER2-positive breast cancer more than standard systemic therapy alone.

  Recruiting at 59 sites Phase 3 SWOG Cancer Research Network · Jonesboro, Arkansas and 58 other locations · NCT07578116

• Advanced NSCLC with actionable mutations after targeted therapy and chemo: expanded Lung-MAP treatment

  This phase II trial tests whether sacituzumab govitecan alone, ivonescimab alone, or the combination of both can help people with advanced or recurrent NSCLC that has a targetable genetic change.

  Recruiting at 41 sites Phase 2 SWOG Cancer Research Network · Berkeley, California and 40 other locations · NCT07393555

• Adding a probiotic to standard immunotherapy for advanced kidney cancer

  This trial tests whether adding MO-03 probiotic to standard immunotherapy helps people with advanced or metastatic clear cell kidney cancer.

  Recruiting at 41 sites Phase 3 SWOG Cancer Research Network · Fayetteville, Arkansas and 40 other locations · NCT07383441

• Educational program to support goals of care conversations for patients with solid cancers

  A-PACT is a program where trained lay health workers help adults with solid tumors talk with their care teams about goals of care and end-of-life preferences to see if it lowers unplanned hospital visits.

  Recruiting at 7 sites SWOG Cancer Research Network · Little Rock, Arkansas and 6 other locations · NCT07278739

• Pirtobrutinib added to R-CHOP for newly diagnosed Richter transformation in Lymphoma

  This trial tests whether adding pirtobrutinib to the standard R-CHOP treatment helps people with Richter transformation (a CLL/SLL that becomes aggressive LBCL).

  Recruiting at 62 sites Phase 3 SWOG Cancer Research Network · Irvine, California and 61 other locations · NCT07220187

• Using the Current Together After Cancer (CTAC) website to improve follow-up care for colorectal cancer survivors

  This trial tests whether the CTAC website helps people with resected stage II or III colorectal cancer and a chosen adult supporter get recommended follow-up care that follows guidelines.

  Recruiting at 383 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 383 other locations · NCT07018869

• Adding panitumumab to chemotherapy for unresectable or metastatic KRAS wild-type pancreatic cancer

  This trial will test whether giving the antibody panitumumab along with standard chemotherapy helps people with unresectable, locally advanced, or metastatic KRAS wild-type pancreatic cancer live longer.

  Recruiting at 272 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 273 other locations · NCT06998940

• Lanreotide versus placebo before surgery to prevent a pancreatic fistula

  This trial will see if giving lanreotide before a planned distal pancreatectomy lowers the risk of a pancreatic fistula in adults with pancreatic cancer or a suspicious pancreatic lesion.

  Recruiting at 18 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 117 other locations · NCT06807437

• Biomarker-guided personalized maintenance treatments for extensive-stage small cell lung cancer

  This phase II trial tests whether biomarker tests on a patient's tumor can guide personalized maintenance drug combinations for people with extensive-stage small cell lung cancer.

  Recruiting at 146 sites Phase 2 SWOG Cancer Research Network · Loma Linda, California and 147 other locations · NCT06769126

• Combining cemiplimab with standard treatment for advanced lung cancer

  This study is testing if adding the immunotherapy drug cemiplimab to standard treatments can help people with advanced lung cancer live longer and feel better compared to just the standard treatments alone.

  Recruiting at 399 sites Phase 2/3 SWOG Cancer Research Network · Daphne, Alabama and 412 other locations · NCT06616584

• Combining Carboplatin with Cabazitaxel for Advanced Prostate Cancer

  This study is testing if adding carboplatin to cabazitaxel chemotherapy can help men with advanced prostate cancer live longer and feel better compared to just using cabazitaxel alone.

  Recruiting at 174 sites Phase 3 SWOG Cancer Research Network · Fayetteville, Arkansas and 173 other locations · NCT06470243

• Targeted treatment for advanced lung cancer with MET gene amplification

  This study is testing if a new treatment called amivantamab can help people with advanced lung cancer that has extra copies of the MET gene feel better and live longer.

  Recruiting at 250 sites Phase 2 SWOG Cancer Research Network · Jonesboro, Arkansas and 270 other locations · NCT06116682

• Targeted treatment for advanced lung cancer with a specific gene change

  This study is testing if a new lung cancer treatment called tepotinib, with or without another drug called ramucirumab, can help people with advanced non-small cell lung cancer that has a specific gene change.

  Recruiting at 246 sites Phase 2 SWOG Cancer Research Network · Daphne, Alabama and 277 other locations · NCT06031688

• Comparing chemotherapy with and without stem cell transplant for AL amyloidosis

  This study is testing whether adding a stem cell transplant to chemotherapy can help people with newly diagnosed AL amyloidosis live longer and have better organ health.

  Recruiting at 116 sites Phase 3 SWOG Cancer Research Network · Goodyear, Arizona and 116 other locations · NCT06022939

• Shorter chemotherapy and immunotherapy for early-stage triple negative breast cancer

  This study is testing whether a shorter treatment plan of chemotherapy and immunotherapy without certain strong drugs can help people with early-stage triple negative breast cancer do better than the usual longer treatment.

  Recruiting at 923 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 962 other locations · NCT05929768

• Combining new drugs with standard treatment for relapsed large B-cell lymphoma

  This study is testing a new combination of drugs for people with large B-cell lymphoma that has come back or didn’t get better with earlier treatments to see if it works better than the usual options.

  Recruiting at 99 sites Phase 2 SWOG Cancer Research Network · Tucson, Arizona and 103 other locations · NCT05890352

• Carboplatin treatment before surgery for high-risk prostate cancer with BRCA mutations

  This study is testing if giving carboplatin chemotherapy before surgery can help men with high-risk prostate cancer and BRCA mutations have better outcomes.

  Recruiting at 132 sites Phase 2 SWOG Cancer Research Network · Anchorage, Alaska and 132 other locations · NCT05806515

• Comparing cooling and compression methods to prevent nerve damage from chemotherapy

  This study is testing three different ways to help prevent nerve damage from chemotherapy in cancer patients receiving taxane-based treatments to see which method works best.

  Recruiting at 33 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 35 other locations · NCT05642611

• Comparing targeted drug combinations for advanced lung cancer with specific gene changes

  This study is testing different combinations of targeted drugs to see if they can help people with advanced lung cancer that has specific gene changes live longer and feel better.

  Recruiting at 372 sites Phase 2 SWOG Cancer Research Network · Daphne, Alabama and 453 other locations · NCT05642572

• Testing new drug treatments after CAR T-cell therapy for relapsed or refractory lymphoma

  This study is testing if two new drugs can help people with lymphoma who haven't responded to previous CAR T-cell therapy feel better and live longer.

  Recruiting at 89 sites Phase 2 SWOG Cancer Research Network · Tucson, Arizona and 94 other locations · NCT05633615

• Comparing drug combinations for treating newly diagnosed multiple myeloma in patients not suitable for stem cell transplant

  This study is testing different combinations of three drugs to see which works best for people with newly diagnosed multiple myeloma who can't have a stem cell transplant.

  Recruiting at 388 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 396 other locations · NCT05561387

• Using chemotherapy after surgery for high-risk pancreatic neuroendocrine tumors

  This study tests if a combination of two chemotherapy drugs can help prevent cancer from coming back in people who have had surgery for high-risk pancreatic neuroendocrine tumors.

  Recruiting at 381 sites Phase 2 SWOG Cancer Research Network · Anchorage, Alaska and 447 other locations · NCT05040360

• Predicting side effects from immune therapy in cancer patients

  This study is trying to see if certain factors like age and medical history can help predict serious side effects in cancer patients receiving immune therapy, so doctors can make better treatment choices.

  Recruiting at 589 sites SWOG Cancer Research Network · Anchorage, Alaska and 848 other locations · NCT04871542

• Comparing two treatment combinations for melanoma with brain metastases

  This study is testing two different treatment combinations for patients with melanoma that has spread to the brain to see which one helps them live longer without the disease getting worse.

  Recruiting at 303 sites Phase 2 SWOG Cancer Research Network · Birmingham, Alabama and 330 other locations · NCT04511013

• Comparing immunotherapy with and without kidney surgery for metastatic kidney cancer

  This study is testing whether adding kidney surgery to a standard immunotherapy treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 340 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 386 other locations · NCT04510597

• Combining ramucirumab with paclitaxel or FOLFIRI for advanced small bowel cancers

  This study is testing if combining a drug called ramucirumab with either paclitaxel or FOLFIRI can help people with advanced small bowel cancer live longer without their disease getting worse.

  Recruiting at 399 sites Phase 2 SWOG Cancer Research Network · Anchorage, Alaska and 535 other locations · NCT04205968

• A master screening protocol for previously-treated non-small cell lung cancer

  This study is testing a new way to screen for specific cancer markers in people with previously treated non-small cell lung cancer to see if targeted therapies can improve their treatment compared to standard care.

  Recruiting at 950 sites Phase 2/3 SWOG Cancer Research Network · Birmingham, Alabama and 1228 other locations · NCT03851445

• Monitoring breast cancer using serum tumor markers

  This study is testing if using blood tests to monitor hormone receptor positive, HER2 negative metastatic breast cancer can help patients live as long as those who receive standard monitoring while also looking at costs and how patients feel.

  Recruiting at 592 sites SWOG Cancer Research Network · Anchorage, Alaska and 722 other locations · NCT03723928

• Comparing standard therapy with or without surgery or radiation for metastatic prostate cancer

  This study is testing whether adding surgery or radiation to standard treatment helps men with metastatic prostate cancer live longer and feel better compared to just standard treatment alone.

  Recruiting at 297 sites Phase 3 SWOG Cancer Research Network · Gilbert, Arizona and 337 other locations · NCT03678025

• Using carvedilol to prevent heart problems in patients with advanced HER-2-positive breast cancer

  This study is testing if the heart medication carvedilol can help prevent heart problems in patients with advanced HER-2-positive breast cancer who are being treated with trastuzumab.

  Recruiting at 145 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 589 other locations · NCT03418961

Quick answers

How many clinical trials run by SWOG Cancer Research Network are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (31 trials), Puerto Rico (4 trials), Mexico (4 trials), Guam (3 trials), Chile (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 15, Phase 2: 11, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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