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Clinical trials and research at National Cancer Institute, Naples

• 29Clinical trials
• 2Countries

Newest trials

All recruiting trials (29)

• Single microdose [68Ga]Ga-R54 PET scan to image CXCR4 in advanced solid tumors and multiple myeloma

  We will try a single microdose of the PET tracer [68Ga]Ga-R54 to see if it binds CXCR4 in people with advanced solid tumors or multiple myeloma.

  Recruiting Early Phase 1 National Cancer Institute, Naples · Naples, Italia · NCT07577206

• Financial burden in early-stage breast cancer

  This project will see if people with early-stage breast cancer experience meaningful financial hardship during the first year of treatment using the PROFFIT questionnaire.

  Recruiting National Cancer Institute, Naples · Naples · NCT07354165

• Relugolix with SBRT for erectile function recovery after prostate cancer therapy

  This study tests whether men with advanced prostate cancer who stop hormone therapy and receive targeted SBRT can regain erectile function within six months.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples · NCT07302451

• Pembrolizumab plus lenvatinib for vulvar cancer (MITO VULVA-01)

  This trial will test whether combining pembrolizumab with lenvatinib helps people with advanced, recurrent, or unresectable vulvar cancer.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples · NCT07290894

• Neoadjuvant dostarlimab for locally advanced dMMR/MSI‑H rectal cancer in routine practice

  This project will try neoadjuvant dostarlimab in adults with dMMR/MSI‑H stage II–III rectal cancer to see how well it works and how safe it is in real-world clinical care.

  Recruiting National Cancer Institute, Naples · Naples and 1 other locations · NCT07269249

• Second-line regorafenib for advanced RAS-mutant colorectal cancer

  This trial will test whether regorafenib given as a less-intensive, personalized second-line option can preserve quality of life and extend survival for people with RAS‑mutant metastatic colorectal cancer who had a long first-line benefit or have only one metastatic site.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples, Italy · NCT07213570

• Adding simvastatin to nivolumab and oxaliplatin-based chemotherapy for ARID1A‑mutated advanced gastroesophageal cancer

  This trial will test whether adding daily simvastatin to nivolumab plus oxaliplatin-based chemotherapy helps people with HER2-negative, ARID1A-mutated advanced gastroesophageal cancer stay progression-free longer.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples, Italia · NCT07213557

• Single‑incision da Vinci SP robotic surgical staging for endometrial cancer

  This study will try using the da Vinci SP single‑port robotic system to perform surgical staging in adults with endometrial cancer to see how it works and how patients recover.

  Recruiting at 3 sites National Cancer Institute, Naples · Naples, Napoli and 2 other locations · NCT07027046

• Discovering tumor antigens for innovative cancer treatments in liver cancer

  This study is trying to find new cancer treatments for liver cancer by looking at the gut bacteria in patients and seeing how it compares to healthy people and those with other cancers.

  Recruiting National Cancer Institute, Naples · Naples · NCT06905262

• Biomarker analysis for patients with advanced head and neck cancer

  This study is testing if certain biomarkers in biopsy samples can help predict how well patients with advanced head and neck cancer will respond to their treatment.

  Recruiting National Cancer Institute, Naples · Naples · NCT06905145

• Creating a network for precision oncology in central-southern Italy

  This study is trying to create a network of labs in central-southern Italy to better understand cancer by improving testing methods and sharing information about tumors to help personalize treatment for patients.

  Recruiting National Cancer Institute, Naples · Naples · NCT06894823

• Using metabolomic profiling to screen for endometrial cancer

  This study is testing a new way to use blood samples to see if certain markers can help identify endometrial cancer in women compared to other types of growths and cancers.

  Recruiting National Cancer Institute, Naples · Naples · NCT06893861

• Tele-consultation to improve colonoscopy quality and reduce anxiety

  This study tests if a tele-consultation with nurses can help people getting a colonoscopy feel less anxious and better prepared for the procedure compared to standard care.

  Recruiting National Cancer Institute, Naples · Naples · NCT06887244

• Exploring the link between colon cancer and chronic kidney disease

  This study is trying to see how chronic kidney disease affects the growth of early-stage colon cancer in patients who are having surgery.

  Recruiting National Cancer Institute, Naples · Naples · NCT06886282

• Advanced cancer diagnosis using multi-omic profiling

  This study is testing a new way to improve cancer diagnosis by using a mix of biological samples and medical images to help doctors choose the best treatments for patients in Italy.

  Recruiting National Cancer Institute, Naples · Naples · NCT06884878

• Adding valproic acid to panitumumab and irinotecan for metastatic colorectal cancer rechallenge

  This trial tests whether giving oral valproic acid along with panitumumab and irinotecan helps people with RAS/BRAF wild-type metastatic colorectal cancer who are being rechallenged with anti‑EGFR therapy.

  Recruiting at 3 sites Phase 2 National Cancer Institute, Naples · Caserta, CE and 7 other locations · NCT06714357

• Comparing intermittent and continuous treatment for metastatic colorectal cancer

  This study is testing whether taking a cancer treatment in breaks instead of continuously can work just as well for people with a specific type of metastatic colorectal cancer.

  Recruiting Phase 3 National Cancer Institute, Naples · Naples · NCT06509126

• Neoadjuvant chemotherapy and immunotherapy for advanced cholangiocarcinoma

  This study is testing a combination of chemotherapy and immunotherapy before surgery to see if it can help people with advanced cholangiocarcinoma have fewer cancer recurrences within a year after their operation.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples, Italia and 5 other locations · NCT06341764

• Collecting cancer patient data in the Campania region

  This study is gathering information from cancer patients in the Campania region to see how their treatment and care can be improved.

  Recruiting at 17 sites National Cancer Institute, Naples · Avellino, Avellino and 16 other locations · NCT06270602

• Understanding the mechanisms behind squamous cell carcinomas

  This study is trying to learn more about squamous cell carcinoma by looking at samples from patients to see how certain markers and cells affect the disease and its treatment.

  Recruiting at 4 sites National Cancer Institute, Naples · Bari, Bari and 3 other locations · NCT06236464

• Evaluating financial distress in ovarian cancer treatment

  This study is trying to see how different treatment plans for ovarian cancer affect the financial stress that patients experience over time.

  Recruiting National Cancer Institute, Naples · Naples · NCT06032975

• Combining Valproic Acid and Simvastatin with Gemcitabine and Nab-paclitaxel for Metastatic Pancreatic Cancer

  This study is testing if adding valproic acid and simvastatin to standard chemotherapy can help people with untreated metastatic pancreatic cancer live longer without their disease getting worse.

  Recruiting at 5 sites Phase 2 National Cancer Institute, Naples · Naples, Italy and 4 other locations · NCT05821556

• Exploring selenoproteins in breast cancer prognosis and treatment.

  This study is testing whether selenoproteins can help predict outcomes and guide treatment for people with triple-negative breast cancer.

  Recruiting at 2 sites National Cancer Institute, Naples · Naples, Napoli and 1 other locations · NCT05817227

• Observational study on rare gynecological cancers

  This study is trying to learn more about rare gynecological cancers to improve treatment and care for patients facing these conditions.

  Recruiting at 2 sites National Cancer Institute, Naples · Milan and 1 other locations · NCT05733806

• Comparing Olaparib to Platinum Chemotherapy for Recurrent Ovarian Cancer After Surgery

  This study is testing if a new drug called olaparib can help women with recurrent ovarian cancer feel better after surgery compared to the usual platinum chemotherapy.

  Recruiting Phase 3 National Cancer Institute, Naples · Naples · NCT05255471

• Evaluating Cabozantinib and Temozolomide for Lung and GEP Neuroendocrine Tumors

  This study is testing if combining two medications, Cabozantinib and Temozolomide, can help people with advanced lung and gastroenteropancreatic neuroendocrine tumors who haven't responded to other treatments.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples, Campania · NCT04893785

• Evaluating the effects of radiation therapy on colorectal cancer patients with lung-limited metastases

  This study is testing if a special type of radiation therapy can help people with colorectal cancer that has spread to their lungs by looking at changes in their tumor DNA and genetics before and after treatment.

  Recruiting National Cancer Institute, Naples · Naples, NAPOLI · NCT04854213

• Assessing cancer pain using machine learning and telemedicine

  This study is testing a new way to help cancer patients manage their pain better by using technology and support from healthcare teams while they stay at home.

  Recruiting National Cancer Institute, Naples · Naples, Campania and 1 other locations · NCT04726228

• Treatment for Stage IV Colorectal Cancer with Folfiri and Cetuximab

  This study is testing if a combination of Folfiri and Cetuximab can help people with stage IV colorectal cancer who have a specific gene type feel better and improve their treatment results.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples · NCT03874026

Quick answers

How many clinical trials run by National Cancer Institute, Naples are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in Italy (29 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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