Zelpultide Alfa to Prevent BPD in High-Risk Preterm Babies

Who could benefit from this research

What this research studies

This study is a Phase 2b/3 trial that will test if zelpultide alfa, a recombinant human SP-D, can reduce breathing-related complications in preterm neonates at high risk for BPD. It compares two dosing levels to standard care and placebo in a multicenter, randomized, double-blind design with adaptive elements. If successful, the treatment could offer a new way to address the underlying inflammation and oxidative stress linked to BPD. Participants will be very preterm infants enrolled across about 90 international sites, with safety and efficacy monitored closely. The goal is to provide evidence for a preventive option that could improve long-term respiratory outcomes for these vulnerable babies.

Why it matters

Where this research is happening

• Airway Therapeutics, INC.
  Atlanta, United States Active

Researchers

• Principal investigator: Salzberg, Marc — Airway Therapeutics, INC.
• Study coordinator: Salzberg, Marc

Related research

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.