Virology Core for HBV/HIV Cure Research
Official title: Virology Core
Funded at Johns Hopkins University · NIH-11600328 · Data updated 2026-11-12
A Johns Hopkins team runs standardized HBV tests and develops new assays to support multiple projects in the HBV/HIV cure effort, using participant samples collected across several sites.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $20,224 |
| NIH project number | 3U19AI188551-02S1 |
| Project ID | NIH-11600328 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV and/or hepatitis B infection who are enrolled in the HBV/HIV Cure Consortium studies and provide samples for testing.
✕Less likely to help
Patients not participating in the consortium or not undergoing HBV/HIV-related testing may not directly benefit.
What this research studies
The Virology Core provides precise, standardized HBV testing on participant samples and generates high-quality data for use in all BICC projects. It also optimizes existing assays and creates new ones to help each project move forward. In addition, the Core supports the use of lab models to advance experiments across participating sites worldwide. This work is integrated with a Shared Resources Core and involves collaboration with diverse sites in the US and across international partner countries. The goal is to better understand HBV dynamics during HIV co-infection and treatment to move toward a functional cure.
Why it matters
Potential benefit: If successful, patients with hepatitis B and HIV could see more effective strategies that might lead to a functional cure and better long-term liver health.
How similar studies have gone: Previous work has established HBV testing platforms; this grant aims to optimize and expand them across multiple projects, combining novel assays with standard methods.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.