Using tiny cell packages to quiet HIV in the brain
Cell-derived extracellular vesicle mediated epigenetic silencing of HIV in the brain
This work explores new ways to deliver special tools to the brain to turn off the HIV virus, aiming for a long-term solution for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Mason University NIH-funded |
| Lab location | 1 site (Fairfax, United States) |
| Project ID | NIH-11081007 on NIH RePORTER |
What this research studies
HIV can hide in the brain, making it hard to treat and contributing to neurological problems. This project is developing a method to deliver genetic tools, called zinc fingers or small hairpin RNAs, directly to HIV-infected cells in the brain using tiny packages called extracellular vesicles. These tools are designed to epigenetically silence, or turn off, the HIV virus, preventing it from making copies of itself. The goal is to find a way to achieve a functional cure for HIV and potentially treat HIV-related brain disorders.
Who could benefit from this research
Good fit: This foundational research is for individuals living with HIV, particularly those concerned about the virus persisting in the brain or experiencing neurological symptoms.
Not a fit: Patients without HIV infection would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could lead to a functional cure for HIV, especially for the virus hidden in the brain, and may help reduce HIV-associated neurological problems.
How similar studies have performed: The researchers have previously shown success with a zinc finger approach delivered by extracellular vesicles, and this work builds on that by comparing it to another genetic tool.
Where this research is happening
Fairfax, United States
- George Mason University — Fairfax, United States (Active)
Researchers
- Principal investigator: Kashanchi, Fatah — George Mason University
- Study coordinator: Kashanchi, Fatah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.