Understanding neuron shapes and connections to help memory-related brain disorders
Official title: Generation and Description of Neuronal Morphology and Connectivity
Funded at George Mason University · NIH-11446489 · Data updated 2026-11-12
This grant builds and shares detailed 3D images of neurons to better understand how brain circuits work in Alzheimer’s disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Mason University NIH-funded |
| Lab location | 1 site (Fairfax, United States) |
| Project start | August 1, 1999 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $397,750 |
| NIH project number | 2R37NS039600-25 |
| Project ID | NIH-11446489 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-intervention study; data come from existing neuron samples and models, not directly recruiting patients.
✕Less likely to help
This project does not include direct patient participation or new clinical procedures.
What this research studies
Researchers will expand NeuroMorpho.Org to store and analyze 3D neuron shapes from the hippocampus and related brain areas, integrating experimental data with computer models of brain activity. The project will enhance software and databases that visualize, reconstruct, and simulate neuron morphology to link cellular structure with memory-related signals. The effort includes collaboration and open access to data so researchers worldwide can study how neuron wiring changes in Alzheimer’s disease.
Why it matters
Potential benefit: If successful, it could improve our understanding of how neuron structure affects memory and potentially guide future therapies.
How similar studies have gone: Previous NeuroMorpho.Org work has created widely used neuron databases and tools, demonstrating value of shared data and models.
Where this research is happening
-
George Mason University
Fairfax, United States Active
Researchers
- Principal investigator: Ascoli, Giorgio a — George Mason University
- Study coordinator: Ascoli, Giorgio a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.