Using nanoelectronics to explore how tiny vesicles help nerves heal
Official title: Nanoelectronics to study exosome circuitry and their role in neuroregeneration
Funded at University of Cincinnati · NIH-11082382 · Data updated 2026-11-12
This study is exploring how electric fields can help nerves heal better by looking at tiny particles that help cells talk to each other, and it’s designed for people with nerve injuries or conditions, aiming to find new ways to improve their recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $401,095 |
| NIH project number | 5R35GM150860-03 |
| Project ID | NIH-11082382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with nerve injuries or conditions affecting the peripheral or central nervous system.
✕Less likely to help
Patients with non-neurological conditions or those who do not have nerve damage may not benefit from this research.
What this research studies
This research investigates how electric fields can stimulate nerve regeneration by focusing on small extracellular vesicles (exosomes) that play a role in cell communication. By electrically stimulating Schwann cells, which are crucial for nerve repair, the study aims to understand how these cells convert bioelectric signals into mechanisms that promote healing. The approach involves developing advanced piezoelectric nanofiber networks that mimic natural electric stimuli, potentially leading to new therapies for neurological disorders. Patients may benefit from insights gained about enhancing nerve repair processes.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve nerve regeneration in patients with neurological injuries or disorders.
How similar studies have gone: Previous research has shown promise in using bioelectric signals to enhance nerve regeneration, indicating that this approach could be a valuable advancement in the field.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Esfandiari, Leyla — University of Cincinnati
- Study coordinator: Esfandiari, Leyla
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.