Using estrogen therapy to improve kidney function after injury
Official title: Estrogen and Serms as Therapy for Renal Ischemia Reperfusion Injury
Funded at University of Pennsylvania · NIH-10905422 · Data updated 2026-11-12
This study is looking at how estrogen therapy might help keep your kidneys healthy after they’ve been injured, like during a transplant, by figuring out how different parts of the kidneys respond to estrogen, so we can find better ways to help patients like you recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $704,454 |
| NIH project number | 1R01DK139679-01 |
| Project ID | NIH-10905422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing kidney transplantation or those at risk of kidney injury due to conditions like cardiac arrest or trauma.
✕Less likely to help
Patients with stable kidney function who are not undergoing transplantation or at risk of ischemia reperfusion injury may not benefit from this research.
What this research studies
This research investigates how estrogen therapy can help protect kidney function after ischemia reperfusion injury (IRI), which often occurs during kidney transplants and other medical emergencies. The study focuses on understanding the roles of different estrogen receptors in the kidneys and how they affect recovery from injury. By using animal models, researchers aim to identify the specific cells and tissues involved in the protective effects of estrogen, with the goal of translating these findings into better treatments for patients undergoing kidney transplantation or experiencing related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney function and longer-lasting transplants for patients who have experienced ischemia reperfusion injury.
How similar studies have gone: Previous research has shown promising results with estrogen therapy in animal models, suggesting potential for success in clinical applications.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Levine, Matthew Howard — University of Pennsylvania
- Study coordinator: Levine, Matthew Howard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.