Using CRISPR technology to better understand complex genetic traits in mice
Official title: Development of approaches to apply CRISPR/Cas9-mediated gene conversion to model complex genetic traits in mice
Funded at University of California, San Diego · NIH-11195703 · Data updated 2026-11-12
This study is exploring new ways to use CRISPR technology in mice to better understand genetic traits linked to diseases like Alzheimer's, which could help create better models for research and lead to new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $521,400 |
| NIH project number | 5R01GM148640-03 |
| Project ID | NIH-11195703 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic predispositions to complex diseases like Alzheimer's or those interested in advancements in genetic therapies.
✕Less likely to help
Patients who do not have genetic conditions or are not interested in genetic research may not receive direct benefits from this research.
What this research studies
This research focuses on developing new methods to apply CRISPR/Cas9 technology for gene conversion in mice, which can help model complex genetic traits associated with diseases like Alzheimer's. By enhancing the ability to transmit specific genetic information across generations, the study aims to improve the understanding of how these traits influence health and disease. The approach involves using genetically encoded tools to precisely edit genes in the germline of mice, potentially leading to more accurate animal models for human diseases. This could ultimately facilitate the development of new therapies and treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective models for studying complex diseases, improving the development of targeted therapies for patients.
How similar studies have gone: Other research has shown promise in using CRISPR technology for gene editing, indicating that this approach could be a significant advancement in understanding genetic traits.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Cooper, Kimberly Lynn — University of California, San Diego
- Study coordinator: Cooper, Kimberly Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.