Using brain stimulation to help people quit smoking

A novel therapeutic application of closed-loop neuromodulation of the brain reward system in nicotine use disorder

NIH-funded research Rutgers the State Univ of Nj Newark · NIH-10832707

This study is testing a new way to help people quit smoking by using a special technique that sends gentle magnetic pulses to the brain, adjusting based on how the brain is responding, to reduce cravings and make it easier to stop smoking.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionRutgers the State Univ of Nj Newark NIH-funded
Lab location1 site (Newark, United States)
Project IDNIH-10832707 on NIH RePORTER

What this research studies

This research investigates a new method of using transcranial magnetic stimulation (TMS) to treat nicotine use disorder by targeting the brain's reward system. The approach involves a closed-loop system that adjusts the stimulation based on real-time brain activity, potentially making the treatment more effective and quicker than traditional methods. Patients will receive targeted brain stimulation aimed at reducing cravings and cigarette consumption, with the goal of improving their chances of quitting smoking. The study aims to refine the TMS protocol to enhance its clinical efficiency and effectiveness.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing nicotine use disorder.

Not a fit: Patients who are not struggling with nicotine addiction or are under 21 years old may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a more effective and faster treatment option for individuals struggling with nicotine addiction.

How similar studies have performed: Previous research has shown promise in using TMS for treating substance use disorders, but this specific closed-loop approach is relatively novel.

Where this research is happening

Newark, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions DisorderDisease
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.