Understanding how intestinal cells use TET3 to control DNA and gene activity
Official title: Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation
Funded at Rutgers the State Univ of Nj Newark · NIH-11377068 · Data updated 2026-11-12
This grant studies how a specific gene (TET3) in gut lining cells changes DNA marks to control which genes are turned on or off, with potential implications for intestinal health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,066,174 |
| NIH project number | 4R01DK139790-03 |
| Project ID | NIH-11377068 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults with healthy or diseased intestinal tissue or those who could donate samples to study DNA modification and gene regulation in the gut.
✕Less likely to help
Individuals without access to intestinal tissue samples or those not affected by gut diseases may not directly benefit.
What this research studies
Researchers will examine how TET3 drives DNA oxidation and regulation of gene activity in intestinal epithelial cells, exploring how environmental factors like microbiota and stress influence these processes. The project combines molecular analyses of DNA modifications with experiments in human intestinal tissue or cells to map when and where TET3 acts. The goal is to uncover mechanisms that maintain healthy gut cell function and how disruptions may contribute to disease. Findings could point to new ways to support gut health or prevent bowel diseases.
Why it matters
Potential benefit: A better understanding of TET3’s role could lead to new approaches for maintaining intestinal health and preventing gut disorders.
How similar studies have gone: Previous work has shown that TET enzymes influence DNA methylation dynamics, supporting potential relevance of this approach.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Etchegaray, Jean-Pierre — Rutgers the State Univ of Nj Newark
- Study coordinator: Etchegaray, Jean-Pierre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.