Using a transparent fish model to study immune processes and diseases
Danionella cerebrum as a transparent vertebrate adult model for studying immune-related biological processes and diseases
This study is using a tiny, see-through fish to watch how immune cells work in real-time, helping us learn more about diseases and aging, so we can better understand how our immune system responds.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10772174 on NIH RePORTER |
What this research studies
This research focuses on developing Danionella cerebrum, a small, transparent fish, to investigate immune-related biological processes and their effects on diseases. By utilizing this unique model, researchers can perform live imaging to observe how immune cells behave in real-time, particularly as they relate to disease progression and aging. The study aims to establish the necessary infrastructure for using this fish as a model organism, leveraging advanced genetic techniques to enhance our understanding of immune dynamics in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are interested in immune-related health issues.
Not a fit: Patients with conditions unrelated to immune processes or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into immune-related diseases and potentially improve treatment strategies.
How similar studies have performed: Previous research using zebrafish models has shown success in studying similar immune processes, suggesting potential for this novel approach.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Lam, Pui Ying — Medical College of Wisconsin
- Study coordinator: Lam, Pui Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.