Understanding why BMI1 and MEL18 act differently in cells
Official title: Identifying the molecular differences between oncogenic BMI1 and its tumor suppressive paralog, MEL18
Funded at Midwestern University (Glendale Az) · NIH-11444961 · Data updated 2026-11-12
Aimed at autistic disorder, this project looks at two proteins that are very similar but have opposite effects on cell growth, to uncover clues that could lead to better treatments in the future.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Midwestern University (Glendale Az) NIH-funded |
| Lab location | 1 site (Glendale, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $527,250 |
| NIH project number | 1R15CA317831-01 |
| Project ID | NIH-11444961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with autistic disorder who may participate in related future studies or whose samples could be used to explore epigenetic mechanisms.
✕Less likely to help
Direct benefit is unlikely for those not involved in related future studies or whose samples are not used in this research.
What this research studies
This project will study two closely related proteins, BMI1 and MEL18, and how they influence gene regulation in cells. By mapping the parts of each protein that change how they interact with partner molecules, researchers hope to understand why BMI1 often promotes cancer while MEL18 seems to suppress it. The work involves comparing how BMI1 and MEL18 form larger protein complexes and how these complexes affect gene expression. The findings could shed light on cellular pathways relevant to neurodevelopmental conditions like autism. The grant supports a focused, lab-based exploration that could inform future therapies tied to epigenetic regulation.
Why it matters
Potential benefit: Gains in understanding of epigenetic regulation could inform new strategies for cancer and neurodevelopmental disorders, potentially guiding future therapies.
How similar studies have gone: Prior research shows that paralogous proteins can have opposing roles, suggesting this approach could reveal meaningful differences.
Where this research is happening
-
Midwestern University (Glendale Az)
Glendale, United States Active
Researchers
- Principal investigator: Kim, Chongwoo a — Midwestern University (Glendale Az)
- Study coordinator: Kim, Chongwoo a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.