Impact of repeated low oxygen levels on breathing control in the brain
Official title: Effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons
Funded at Midwestern University (Glendale Az) · NIH-10974994 · Data updated 2026-11-12
This study is looking at how repeated drops in oxygen levels during sleep, common in people with sleep apnea, affect the brain's breathing control, specifically focusing on important nerve cells that help keep the airway open.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Midwestern University (Glendale Az) NIH-funded |
| Lab location | 1 site (Glendale, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $421,800 |
| NIH project number | 1R15HL175526-01 |
| Project ID | NIH-10974994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who suffer from obstructive sleep apnea.
✕Less likely to help
Patients without obstructive sleep apnea or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how chronic intermittent hypoxia, often seen in obstructive sleep apnea, affects the brain's ability to control breathing. It focuses on the hypoglossal motoneurons, which are crucial for keeping the airway open during sleep. By examining changes in cholinergic modulation and the activity of these neurons, the study aims to understand the underlying mechanisms that contribute to breathing difficulties in affected individuals. Advanced techniques like immunofluorescence and electrophysiology will be used to gather detailed insights into these processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with obstructive sleep apnea, enhancing their breathing control during sleep.
How similar studies have gone: Previous research has shown that understanding the effects of hypoxia on neural function can lead to significant advancements in treating sleep-related breathing disorders.
Where this research is happening
-
Midwestern University (Glendale Az)
Glendale, United States Active
Researchers
- Principal investigator: Revill, Ann Louise — Midwestern University (Glendale Az)
- Study coordinator: Revill, Ann Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.