Understanding the Ovary's Environment to Restore Function
Reverse Engineering the Extracellular Neighborhood to Support the Functional Tissue Unit: A Use Case to Restore Ovarian Function
This work aims to deeply understand how a healthy human ovary works to help women with premature ovarian insufficiency.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11170488 on NIH RePORTER |
What this research studies
Our goal is to create a detailed map of the healthy human ovary, looking at how it changes over time from puberty, how different parts of it are organized, and how its cells mature and produce hormones. We believe that by understanding these key dimensions, we can better identify and understand diseases like premature ovarian insufficiency. This knowledge will then help us develop new and safer ways to restore fertility and hormone balance for patients.
Who could benefit from this research
Good fit: This foundational work is ultimately for women who experience premature ovarian insufficiency and are seeking options for fertility or hormone restoration.
Not a fit: Patients who do not have ovarian issues or are not seeking fertility or hormone restoration may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to improved and longer-lasting options for fertility and hormone restoration for women with premature ovarian insufficiency.
How similar studies have performed: This project is building a comprehensive, multi-dimensional atlas of the human ovary, which is a novel approach to understanding its complex biology.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Laronda, Monica M — Lurie Children's Hospital of Chicago
- Study coordinator: Laronda, Monica M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.