Understanding the ovarian environment to improve fertility treatments
Reverse Engineering the Extracellular Neighborhood to Support the Functional Tissue Unit: A Use Case to Restore Ovarian Function
This study is looking at how changes during puberty affect the ovaries, with the goal of helping women who have trouble with fertility or hormone production, so they can have better treatment options in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10886743 on NIH RePORTER |
What this research studies
This research aims to enhance our understanding of the ovarian environment by exploring how different factors change during puberty and affect ovarian function. By examining the biochemical and physical properties of the extracellular matrix and how they interact with ovarian cells, the study seeks to create a more comprehensive atlas of ovarian health. This information could lead to improved regenerative medicine techniques for restoring fertility and hormone production in women with premature ovarian insufficiency.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing premature ovarian insufficiency or those interested in fertility restoration.
Not a fit: Patients who do not have ovarian function issues or are not seeking fertility treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better fertility restoration options and improved quality of life for women with premature ovarian insufficiency.
How similar studies have performed: Previous research has shown promise in using similar approaches to enhance understanding of ovarian function and improve fertility treatments.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Laronda, Monica M — Lurie Children's Hospital of Chicago
- Study coordinator: Laronda, Monica M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.