Understanding the genetic changes in plasma cell cancers
Official title: Bioinformatics Core
Funded at Baylor College of Medicine · NIH-10910174 · Data updated 2026-11-12
This study is looking at the genetic changes in people with MGUS to understand how it might develop into more serious conditions like multiple myeloma, so we can find ways to help prevent or delay cancer for those at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $116,279 |
| NIH project number | 5U54CA272691-02 |
| Project ID | NIH-10910174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with MGUS who are being monitored for potential progression to multiple myeloma or related conditions.
✕Less likely to help
Patients who have already developed multiple myeloma or Waldenstrom’s macroglobulinemia may not benefit directly from this research.
What this research studies
This research focuses on analyzing genetic changes in patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma and Waldenstrom’s macroglobulinemia. By examining tissue samples and bone marrow biopsies from patients, the project aims to uncover the mechanisms that lead to the progression from MGUS to more severe malignancies. The Bioinformatics Core will utilize advanced genomic analysis techniques to provide insights into how these precancerous cells interact with the bone marrow environment and immune system. This research is part of a larger effort to develop strategies to prevent or delay the onset of cancer in at-risk individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the progression of MGUS to multiple myeloma or Waldenstrom’s macroglobulinemia.
How similar studies have gone: Previous research has shown promise in understanding the genetic basis of plasma cell malignancies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Shaughnessy, John Damian — Baylor College of Medicine
- Study coordinator: Shaughnessy, John Damian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.