Understanding the genetic causes of a rare skin condition linked to HPV
Molecular and cellular basis of epidermodysplasia verruciformis
This study is looking at a rare skin condition called epidermodysplasia verruciformis, which makes people more likely to get certain skin infections from viruses, and it aims to find out what genetic changes cause this condition and how they affect the immune system, so patients can better understand their health and the risks of skin issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10763373 on NIH RePORTER |
What this research studies
This research investigates epidermodysplasia verruciformis (EV), a rare genetic condition that makes individuals susceptible to certain skin infections caused by human papillomaviruses (HPVs). The study focuses on identifying the genetic mutations that lead to this condition and how they affect the immune response to these viruses. By analyzing the genetic makeup of affected individuals, researchers aim to uncover the underlying mechanisms that contribute to the development of flat warts and their potential progression to skin cancer. Patients may be involved in genetic testing and monitoring to better understand their condition and its implications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epidermodysplasia verruciformis or those with a family history of the condition.
Not a fit: Patients with other unrelated skin conditions or those without a genetic predisposition to HPV infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with epidermodysplasia verruciformis.
How similar studies have performed: Previous research has successfully identified genetic mutations associated with similar immunodeficiencies, suggesting a promising avenue for understanding epidermodysplasia verruciformis.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Casanova, Jean-Laurent — Rockefeller University
- Study coordinator: Casanova, Jean-Laurent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.