Understanding the causes of major depression through genetic and environmental factors
Risk Pathways to Major Depression: Integrating Genetic-Epidemiological, Developmental, and Molecular Genetic Strategies in Danish and Swedish National Registers
This study is looking at how our genes and life experiences work together to cause major depression, using data from Denmark and Sweden, to help find better ways to prevent and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11108510 on NIH RePORTER |
What this research studies
This research investigates the complex causes of major depression by examining how genetic and environmental factors interact over time. Using comprehensive data from national registers in Denmark and Sweden, the study aims to identify specific genetic risk profiles and environmental stressors that contribute to the development of depression. The research team will utilize innovative methods, such as Family Genetic Risk Scores, to analyze the genetic backgrounds of individuals and their families. By understanding these risk pathways, the research hopes to provide insights that could lead to better prevention and treatment strategies for major depression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of major depression or related disorders, as well as those experiencing significant life stressors.
Not a fit: Patients who do not have a family history of major depression or who are not experiencing environmental stressors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of individuals at risk for major depression and more effective prevention strategies.
How similar studies have performed: Previous research has shown success in understanding the genetic and environmental factors contributing to mental health conditions, making this approach both promising and relevant.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Kendler, Kenneth Seedman — Virginia Commonwealth University
- Study coordinator: Kendler, Kenneth Seedman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.