Understanding TDP43 Mislocalization in Aging and ALS-FTLD-LATE
Official title: Structural interrogation of TDP43 mislocalization and aggregation in aging and disease
Funded at University of Michigan at Ann Arbor · NIH-11606637 · Data updated 2026-11-12
Researchers are studying how the TDP43 protein misfolds and clumps in aging brains, to help people with ALS and related disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 14, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $555,275 |
| NIH project number | 1R56NS147344-01 |
| Project ID | NIH-11606637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with ALS, FTLD, or LATE, or those contributing brain tissue samples or cells derived from patients.
✕Less likely to help
Participants directly recruited for this study are not described; results may primarily come from donated tissue and derived cells.
What this research studies
This project uses human brain tissue and patient-derived neurons to map how TDP43 structure changes in different brain regions and diseases. It looks at age-related factors that influence these changes and how they affect cell biology and disease progression. By connecting specific TDP43 shapes to different disorders, the study aims to identify biomarkers and new targets for therapies. The work relies on post-mortem samples and iNeurons to model disease in a clinically relevant way.
Why it matters
Potential benefit: Findings could lead to biomarkers and new treatment strategies for ALS and related TDP43 proteinopathies.
How similar studies have gone: Prior studies have linked TDP43 mislocalization to neurodegenerative diseases, with ongoing efforts to translate this knowledge into biomarkers and therapies.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Barmada, Sami — University of Michigan at Ann Arbor
- Study coordinator: Barmada, Sami
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.