Understanding Neutrophils in Inflammation and Heart Disease
Neutrophil Mechanisms During Inflammation and Atherosclerosis
['FUNDING_P01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11187033
This work explores how certain immune cells called neutrophils contribute to inflammation and heart conditions like coronary artery disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11187033 on ClinicalTrials.gov |
What this research studies
Our bodies' immune cells, called neutrophils, play a key role in inflammation, and when they become overactive, it can lead to conditions like heart disease and autoimmune disorders. We are learning how these neutrophils develop and how their internal processes, like transporting important molecules, affect their activity. By understanding these processes, especially in the context of high-fat diets and inflammation, we hope to find new ways to control harmful inflammation. This knowledge could lead to new treatments for heart disease and other inflammatory conditions.
Who could benefit from this research
Good fit: This foundational work is relevant to individuals living with or at risk for atherosclerotic cardiovascular disease, coronary artery disease, and autoimmune conditions.
Not a fit: Patients without inflammatory conditions or heart disease are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could identify new targets for medications to reduce harmful inflammation in conditions like coronary artery disease and autoimmune diseases.
How similar studies have performed: While the specific approach of targeting neutrophil vesicular trafficking is unique, other studies have shown the importance of neutrophils in inflammation and heart disease.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CATZ, SERGIO DANIEL — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: CATZ, SERGIO DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, Autoimmune Diseases