Understanding movement changes in Alzheimer's disease using mouse models
Neurobehavioral phenotyping of AD model mice using Motion Sequencing
This study is looking at how Alzheimer's disease affects movement and behavior in mice to find early signs of the disease before memory problems start, which could help us understand how Alzheimer's changes the way we move as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10883911 on NIH RePORTER |
What this research studies
This research investigates how Alzheimer's disease (AD) affects movement and behavior in mouse models. By analyzing changes in body movement, such as slowed gait and difficulty avoiding obstacles, the study aims to identify early indicators of AD before cognitive symptoms appear. The researchers will use advanced motion sequencing techniques to gain insights into the neural circuits involved in these behaviors, helping to differentiate between normal aging and AD-related changes. This approach may lead to a better understanding of the disease's progression and its impact on motor functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better understanding of Alzheimer's disease, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using behavioral analysis in animal models to understand neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Datta, Sandeep R — Harvard Medical School
- Study coordinator: Datta, Sandeep R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.