Motion-based mapping of movement changes in Alzheimer's models
Neurobehavioral phenotyping of AD model mice using Motion Sequencing
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11138604
Researchers are using advanced motion-tracking in mice to find early movement changes linked to Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11138604 on ClinicalTrials.gov |
What this research studies
This project uses a new motion-sequencing technique to record and analyze how Alzheimer’s-related brain changes affect mice's natural movements. Scientists will track 3-D movements across different Alzheimer's mouse models to look for shared movement patterns and to separate disease effects from normal aging. By comparing detailed behavior across models, the team aims to identify the brain circuits that cause movement and action-selection problems in Alzheimer's. Although the work is done in mice, the findings could point to movement-based markers for early disease and guide future human studies.
Who could benefit from this research
Good fit: People with Alzheimer's disease, those with early movement or memory symptoms, and individuals at higher risk could be future candidates for related human studies inspired by this work.
Not a fit: This grant supports mouse research and does not provide direct treatment or enrollment opportunities for patients at this time.
Why it matters
Potential benefit: If successful, the work could help identify early movement signs of Alzheimer's and guide new ways to detect or treat the disease.
How similar studies have performed: Traditional mouse movement tests have produced inconsistent results, and applying motion sequencing to Alzheimer's models is a newer, relatively untested approach.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DATTA, SANDEEP R — HARVARD MEDICAL SCHOOL
- Study coordinator: DATTA, SANDEEP R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model