Understanding molecular markers of COPD using advanced network analysis
Official title: Statistical physics and network-based approaches for elucidating molecular biomarkers of COPD
Funded at Brigham and Women's Hospital · NIH-10872122 · Data updated 2026-11-12
This study is looking at chronic obstructive pulmonary disease (COPD) to find new clues about how it works and what causes it, using advanced techniques to analyze data about proteins in the body, which could help improve treatments for people living with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $189,000 |
| NIH project number | 5K25HL166208-02 |
| Project ID | NIH-10872122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with chronic obstructive pulmonary disease (COPD) who are seeking new treatment options.
✕Less likely to help
Patients with other respiratory conditions that are not classified as COPD may not benefit from this research.
What this research studies
This research focuses on chronic obstructive pulmonary disease (COPD), a serious lung condition that leads to breathing difficulties. By employing statistical physics and network-based approaches, the study aims to identify molecular biomarkers that can help in understanding the disease's complex mechanisms. The researchers will analyze multi-omics data to uncover interactions within the human protein-protein interaction network, which may reveal critical insights into COPD pathogenesis. This innovative approach seeks to improve the prediction of disease genes and inform potential therapeutic strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted treatments for COPD patients.
How similar studies have gone: Previous research using network-based approaches has shown promise in elucidating complex diseases, suggesting that this methodology could yield valuable insights for COPD as well.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Xuwen — Brigham and Women's Hospital
- Study coordinator: Wang, Xuwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.