Understanding malaria rebound in kids after seasonal protection in Mali
Official title: "Investigating the rebound effects of seasonal malaria chemoprevention (SMC) in Mali"
Funded at Univ of Sciences, Tech & Tech of Bamako · NIH-11412643 · Data updated 2026-11-12
This NIH-funded project in Mali checks whether children stop getting protection from seasonal malaria drugs too soon and what factors shape any rebound in malaria risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Sciences, Tech & Tech of Bamako NIH-funded |
| Lab location | 1 site (Bamako, Mali) |
| Project start | September 5, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $130,918 |
| NIH project number | 5R01AI169517-05 |
| Project ID | NIH-11412643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children in Mali who have received SMC and are entering ages beyond the eligible window for continued protection.
✕Less likely to help
Children who have not received SMC or who live outside Sahel regions may not benefit from these findings.
What this research studies
In sub-Saharan Africa, young children are protected during certain months by Seasonal Malaria Chemoprevention (SMC). This study, set in Mali, follows children as they age out of SMC to see if their malaria risk increases afterward. Researchers will look at biological, epidemiological, and immunologic clues to understand why risk might change over time. The work also aims to strengthen local laboratories, surveillance, and collaborations between U.S. and Malian scientists. Findings could help optimize SMC programs across Sahel countries and beyond.
Why it matters
Potential benefit: If successful, the study could help health programs fine-tune SMC timing to protect more children more cost-effectively.
How similar studies have gone: Previous research has shown strong protection with SMC, but evidence on rebound risk after stopping SMC is limited and this study seeks to address that gap.
Where this research is happening
-
Univ of Sciences, Tech & Tech of Bamako
Bamako, Mali Active
Researchers
- Principal investigator: Toure, Mahamoudou — Univ of Sciences, Tech & Tech of Bamako
- Study coordinator: Toure, Mahamoudou
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.