Understanding lymphatic issues in neurodevelopmental disorders and their effects on behavior
Official title: Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11047093 · Data updated 2026-11-12
This study looks at how problems with the lymphatic system might affect social behavior in mice with Fragile X Syndrome, aiming to find ways to improve these behaviors by better understanding the role of a specific gene.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 16, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $241,500 |
| NIH project number | 1R01MH133584-01A1 |
| Project ID | NIH-11047093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or related neurodevelopmental disorders.
✕Less likely to help
Patients without neurodevelopmental disorders or those over the age of 21 may not benefit from this research.
What this research studies
This research investigates how lymphatic dysfunction affects social behavior in a mouse model of Fragile X Syndrome. The study focuses on the role of the fmr1 gene, which is crucial for lymphatic function and is linked to behavioral impairments. By examining the lymphatic system's development and its impact on immune cell regulation, the research aims to uncover the molecular mechanisms that contribute to these disorders. The findings could lead to new insights into how improving lymphatic function might enhance social behaviors in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving social behaviors in individuals with neurodevelopmental disorders like Fragile X Syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of lymphatic function in brain health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Louveau, Antoine — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Louveau, Antoine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.