Understanding immune dysfunction in chronic Hepatitis C infection
Official title: Defining Immune Dysfunction in Chronic Hepacivirus Infection at Single Cell Resolution
Funded at Icahn School of Medicine at Mount Sinai · NIH-10996382 · Data updated 2026-11-12
This study is looking at how chronic Hepatitis C infection affects the immune system, especially how certain immune cells called T cells lose their ability to fight the virus over time, using a special mouse model to better understand these changes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI186462-01 |
| Project ID | NIH-10996382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic Hepatitis C who may benefit from advancements in treatment options.
✕Less likely to help
Patients with acute Hepatitis C or those who have cleared the virus may not receive direct benefits from this research.
What this research studies
This research investigates how the immune system is affected by chronic Hepatitis C virus (HCV) infection, focusing on the role of T cells that become ineffective over time. Using a novel animal model, the study aims to characterize the immune response at a single-cell level, providing insights into the mechanisms behind immune dysfunction. By examining the immune landscape in mice infected with a closely related virus, the research seeks to uncover the factors that contribute to the persistence of the virus and the challenges in mounting an effective immune response.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for patients with chronic Hepatitis C infection.
How similar studies have gone: Previous research has shown promise in using animal models to study chronic viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Bobrowski, Tesia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bobrowski, Tesia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.