Understanding human diseases using zebrafish models
Official title: Multimodal phenotyping of zebrafish models of human disease
Funded at University of Utah · NIH-11113836 · Data updated 2026-11-12
This study is exploring how scientists can use zebrafish to better understand human diseases by using cool tools like CRISPR, which helps them change genes, and new methods to quickly create and study these models, making it easier to see how genetic changes can impact health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $769,325 |
| NIH project number | 5R24OD035409-02 |
| Project ID | NIH-11113836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic diseases that could be modeled in zebrafish.
✕Less likely to help
Patients with conditions that cannot be modeled in zebrafish or those not related to genetic factors may not receive benefits from this research.
What this research studies
This research investigates how zebrafish can be used to model human diseases by employing advanced technologies like CRISPR and high-throughput gene disruption. By utilizing a method called Multiplexed, Intermixed CRISPR Droplets (MIC-Drop), researchers aim to create and analyze disease models more efficiently than ever before. The study focuses on generating detailed phenotypic data through automated physiological and behavioral assays, which will help in understanding the genetic basis of diseases. This approach allows for a systematic characterization of how genetic changes affect health and disease.
Why it matters
Potential benefit: If successful, this research could lead to more targeted and effective treatments for various human diseases.
How similar studies have gone: Other research has shown success using similar approaches in animal models, particularly with CRISPR technology in understanding genetic diseases.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Peterson, Randall T — University of Utah
- Study coordinator: Peterson, Randall T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.