Understanding how Wnt5a-Ror signaling affects development and disease
Mechanisms of mammalian Wnt5a-Ror signaling
This study is looking at how a specific signaling pathway in our bodies affects tissue development and can lead to issues like birth defects and cancer, with the hope of finding new ways to treat these problems for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11086132 on NIH RePORTER |
What this research studies
This research investigates the Wnt5a-Ror signaling pathway, which plays a crucial role in the development of tissues during embryonic growth. It aims to uncover how disruptions in this pathway can lead to birth defects and contribute to cancer metastasis and inflammatory disorders. By studying the mechanisms of Wnt5a secretion and its interaction with receptor proteins, the research seeks to provide insights that could lead to new therapeutic strategies. Patients may benefit from a better understanding of these processes, potentially leading to improved treatments for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with birth defects related to Wnt5a signaling or those affected by cancers linked to this pathway.
Not a fit: Patients with conditions unrelated to Wnt5a-Ror signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for birth defects and cancers associated with Wnt5a-Ror signaling disruptions.
How similar studies have performed: While the Wnt signaling pathway has been extensively studied, the specific mechanisms of Wnt5a-Ror signaling are less understood, making this research a novel exploration.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Huang, Pengxiang — Baylor College of Medicine
- Study coordinator: Huang, Pengxiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.