Understanding how trauma affects the brain, bone marrow, and gut interactions
Official title: The Role of Brain-Bone Marrow-Gut Interaction following Major Trauma
Funded at University of Florida · NIH-10764574 · Data updated 2026-11-12
This study looks at how serious injuries affect the brain, bone marrow, and gut, especially how they can lead to ongoing health issues like anemia and illness, and it's designed for anyone interested in understanding how trauma can impact recovery over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $457,500 |
| NIH project number | 1R35GM152216-01 |
| Project ID | NIH-10764574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced major trauma and are suffering from chronic critical illness or persistent anemia.
✕Less likely to help
Patients who have not experienced major trauma or do not have related chronic conditions may not benefit from this research.
What this research studies
This research investigates the complex interactions between the brain, bone marrow, and gut following major trauma. It focuses on how severe injuries can lead to chronic critical illness and persistent anemia, which are exacerbated by stress and inflammation. The study employs both human and animal models to explore the underlying biological mechanisms, including changes in bone marrow function and the microbiome. By examining these interactions, the research aims to improve our understanding of trauma survivorship and its impact on long-term recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for trauma survivors, enhancing their quality of life and recovery outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the biological responses to trauma, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Mohr, Alicia M — University of Florida
- Study coordinator: Mohr, Alicia M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.