RAAS inhibitors and pancreatic cancer risk in diverse adults
Official title: Pilot Project 7
Funded at University of Florida · NIH-11625597 · Data updated 2026-11-12
A Florida-based study will look at whether commonly used blood pressure medicines (RAAS inhibitors) are linked to new cases of pancreatic cancer, especially among Black and Hispanic adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $172,444 |
| NIH project number | 5U54CA233444-09 |
| Project ID | NIH-11625597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older, especially Black/African American and Hispanic individuals, who may be using or eligible for RAAS inhibitors.
✕Less likely to help
People not using RAAS inhibitors or with conditions where these medications are unsuitable may not see direct benefit.
What this research studies
This project analyzes real-world medical data to see if renin-angiotensin-aldosterone system (RAAS) inhibitors are linked to lower or higher risk of developing pancreatic cancer, with attention to race and genetics. Researchers will use big data approaches to explore associations between RAAS medications and new pancreatic cancer cases, and how genetic variants might change these effects. The work aims to identify potential disparities and inform future prevention strategies for adults aged 21 and up, including those over 65. The team will communicate findings back to communities and healthcare providers to support informed medication choices and cancer prevention efforts.
Why it matters
Potential benefit: If successful, results could influence prescription decisions and reduce pancreatic cancer risk in high-risk groups.
How similar studies have gone: Previous findings suggest RAAS pathways may influence pancreatic cancer biology, but results in diverse populations are limited and exploratory.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Jiao, Tianze — University of Florida
- Study coordinator: Jiao, Tianze
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.