Understanding how transfer RNAs affect blood stem cell function
Official title: Transfer RNAs in Hematopoietic Stem Cell Function
Funded at University of California, San Diego · NIH-10897114 · Data updated 2026-11-12
This study is looking at how tiny molecules called transfer RNAs help blood stem cells work properly, which could lead to new treatments for blood disorders like anemia or blood cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $316,000 |
| NIH project number | 5R01HL165172-02 |
| Project ID | NIH-10897114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with blood disorders such as anemia or those at risk for hematopoietic malignancies.
✕Less likely to help
Patients with non-blood-related conditions or those who do not have any hematological issues may not receive benefit from this research.
What this research studies
This research investigates the role of transfer RNAs (tRNAs) in the function and maintenance of hematopoietic stem cells (HSCs), which are responsible for producing all blood cells. The study aims to uncover how changes in tRNA expression can impact HSC self-renewal and function, potentially leading to conditions like anemia or blood cancers. By examining the mechanisms of mRNA translation in HSCs, the research seeks to identify critical factors that regulate blood cell production and health. Patients may benefit from insights that could lead to new treatments for blood-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for blood disorders and better understanding of blood stem cell function.
How similar studies have gone: Other research has shown promising results in understanding the role of tRNAs in various cellular functions, suggesting potential for success in this area as well.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Ackerman, Susan L — University of California, San Diego
- Study coordinator: Ackerman, Susan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.