Understanding how to create better bone healing tissues
Official title: Molecular control of blood vessel types at the regenerative interface for engineering of osteogenic and angiogenic periosteum mimetic
Funded at University of Rochester · NIH-10897874 · Data updated 2026-11-12
This study is looking at how to create a special tissue that acts like the natural layer around bones to help them heal better, especially for people with big bone injuries, by using smart methods to encourage blood flow and bone growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 2, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $494,149 |
| NIH project number | 5R01AR083224-02 |
| Project ID | NIH-10897874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with large bone defects requiring surgical intervention, such as those with traumatic injuries or certain bone diseases.
✕Less likely to help
Patients with minor bone injuries or those who do not require surgical repair may not benefit from this research.
What this research studies
This research investigates how to engineer a tissue that mimics the periosteum, a natural membrane that helps bones heal. By studying the relationship between blood vessels and bone cells, the team aims to develop a biomimetic tissue-engineered periosteum that enhances the healing of large bone defects. The approach involves using advanced techniques to control the delivery of growth factors that promote both blood vessel formation and bone growth, potentially leading to improved outcomes for patients needing bone repair.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with large bone defects, improving healing times and outcomes.
How similar studies have gone: Previous research has shown promise in tissue engineering approaches for bone repair, indicating that this area of study has potential for significant advancements.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Zhang, Xinping — University of Rochester
- Study coordinator: Zhang, Xinping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.