Understanding how Tie2 signaling affects aortic valve development
Official title: The role of Tie2 signaling in Aortic Valve Remodeling
Funded at Vanderbilt University Medical Center · NIH-11162523 · Data updated 2026-11-12
This study is exploring how a specific signaling pathway in the heart helps shape the aortic valves, which is important for keeping your heart working well, and it aims to find new ways to help people with congenital heart defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 10, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $623,815 |
| NIH project number | 5R01HL173766-02 |
| Project ID | NIH-11162523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with congenital heart malformations, particularly those involving the aortic valve.
✕Less likely to help
Patients with acquired heart conditions unrelated to valve development may not receive benefit from this research.
What this research studies
This research investigates the role of Tie2 signaling in the remodeling of aortic valves, which is crucial for normal heart function. By using advanced genetic models in mice, the study aims to uncover the mechanisms that regulate the later stages of valve development, which are not well understood. The researchers will specifically look at how the TIE2-PI3K/AKT-FOXO1 signaling pathway influences this process. Patients with congenital heart defects may benefit from insights gained through this research, as it could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for congenital heart defects related to aortic valve abnormalities.
How similar studies have gone: Other research has shown success in understanding signaling pathways in heart development, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Baldwin, H Scott — Vanderbilt University Medical Center
- Study coordinator: Baldwin, H Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.