Understanding how tetanus toxin affects the nervous system
Molecular mechanism of tetanus neurotoxin pathogenesis
This study is looking into how the tetanus toxin causes paralysis by figuring out how it connects to nerve cells and affects their function, which could help us learn more about tetanus and find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11104173 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which the tetanus neurotoxin (TeNT) causes paralysis. It focuses on how TeNT binds to host factors and enters the spinal cord, disrupting normal nerve function. The study employs advanced techniques, including X-ray crystallography and genetically modified mouse models, to explore the interactions between the toxin and nerve cells. By understanding these processes, the research aims to uncover new insights into tetanus pathogenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced deep puncture wounds or are at risk of tetanus infection.
Not a fit: Patients who have not been exposed to tetanus or do not have a history of deep wounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies for tetanus and related neurological conditions.
How similar studies have performed: Previous research has successfully identified mechanisms of action for other bacterial toxins, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dong, Min — Boston Children's Hospital
- Study coordinator: Dong, Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.