Understanding how TET3 affects DNA changes in the intestines
Official title: Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation
Funded at Rutgers the State Univ of Nj Newark · NIH-10913686 · Data updated 2026-11-12
This study is looking at how a protein called TET3 affects the DNA in the cells of your gut and how things like gut bacteria and stress can change this DNA, which is important for keeping your intestines healthy, with the hope of finding new treatments for conditions like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $533,907 |
| NIH project number | 1R01DK139790-01 |
| Project ID | NIH-10913686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old, particularly those with or at risk for intestinal bowel diseases.
✕Less likely to help
Patients without any intestinal conditions or those under 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates the role of TET3, a protein involved in DNA modification, in the intestinal epithelial cells. It aims to understand how environmental factors like gut bacteria and stressors influence DNA methylation patterns, which are crucial for maintaining healthy intestinal function. By examining the mechanisms of DNA oxidation and repair, the study seeks to uncover how these processes relate to intestinal diseases. Patients may benefit from insights that could lead to new treatments for conditions like inflammatory bowel disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating intestinal diseases.
How similar studies have gone: Previous research has shown that understanding DNA methylation dynamics can lead to significant advancements in treating various diseases, suggesting this approach has potential for success.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Etchegaray, Jean-Pierre — Rutgers the State Univ of Nj Newark
- Study coordinator: Etchegaray, Jean-Pierre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.