Understanding how sweat glands develop and function
Official title: Mechanisms underlying the formation and function of the sweat gland dermal niche
Funded at University of Pennsylvania · NIH-11078711 · Data updated 2026-11-12
This study is looking at how certain cells help create and keep sweat glands working, which is important for keeping our body cool, and it aims to find ways to help people with skin injuries regain their ability to sweat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $507,330 |
| NIH project number | 5R01AR083938-02 |
| Project ID | NIH-11078711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with skin injuries that impair their ability to sweat and regulate body temperature.
✕Less likely to help
Patients without skin injuries or those who do not experience issues with sweating may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the formation and function of sweat glands, which are crucial for regulating body temperature. It focuses on a specific population of cells known as the Engrailed 1-dependent eccrine niche (EDEN) that plays a vital role in the development of these glands. By studying how EDEN cells contribute to sweat gland formation and maintenance, the research aims to uncover new insights that could help in regenerating sweat glands for patients with skin injuries. The approach includes functional experiments in mice to explore cellular interactions and factors involved in sweat gland development.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from thermoregulation issues due to skin injuries.
How similar studies have gone: While the specific focus on the EDEN niche is novel, similar research has shown promise in understanding skin appendage regeneration.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kamberov, Yana G — University of Pennsylvania
- Study coordinator: Kamberov, Yana G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.