Understanding how stress hormones affect PTSD development
Official title: Glucocorticoid Receptor Mechanisms of Traumatic Stress Pathology
Funded at Cincinnati VA Medical Center Research · NIH-10911027 · Data updated 2026-11-12
This study is looking at how certain hormones in the body might affect the way people, especially military personnel who have gone through trauma, develop post-traumatic stress disorder (PTSD), using animal models to help understand the biology behind it and find better ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati VA Medical Center Research NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| NIH project number | 5I01BX005923-03 |
| Project ID | NIH-10911027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military veterans, particularly women, who have experienced trauma and are at risk for developing PTSD.
✕Less likely to help
Patients who do not have a history of trauma or PTSD may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which glucocorticoid receptors influence the development of post-traumatic stress disorder (PTSD), particularly in individuals who have experienced trauma, such as military personnel. The study aims to explore how hormonal responses to stress may contribute to behavioral pathologies associated with PTSD, using rodent models to emulate human conditions. By examining genetic factors and brain connections involved in fear and anxiety, the research seeks to uncover the biological underpinnings of PTSD, which could lead to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating PTSD, potentially improving the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of glucocorticoid receptors in stress-related disorders, indicating that this approach has potential for significant findings.
Where this research is happening
-
Cincinnati VA Medical Center Research
Cincinnati, United States Active
Researchers
- Principal investigator: Herman, James P — Cincinnati VA Medical Center Research
- Study coordinator: Herman, James P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.