Investigating a fungal pneumonia affecting older adults and immunocompromised patients
BLR&D Research Career Scientist Award Application
This study is looking at a serious lung infection called Pneumocystis pneumonia, which mainly affects older people and those with weakened immune systems, to find out how the fungus that causes it works and to see if current antifungal medicines can be improved to help keep patients healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati VA Medical Center Research NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11105899 on NIH RePORTER |
What this research studies
This research focuses on Pneumocystis pneumonia (PCP), a serious lung infection caused by a fungal pathogen that primarily affects immunocompromised individuals, particularly those over 65 years of age. The study aims to explore the life cycle of the fungus and evaluate the effectiveness of existing antifungal treatments, such as echinocandins, in preventing and treating PCP. By analyzing gene expression and treatment responses in animal models, the research seeks to identify new therapeutic strategies to combat this infection, which has seen a rise in cases among various vulnerable populations. Patients may benefit from advancements in treatment options that could improve outcomes for those at risk of PCP.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 65 and older, particularly those who are immunocompromised due to conditions like HIV, cancer treatments, or chronic inflammatory diseases.
Not a fit: Patients who are not immunocompromised and do not fall within the age range of 65 and older may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new and effective treatments for Pneumocystis pneumonia, significantly improving health outcomes for older adults and immunocompromised patients.
How similar studies have performed: Previous studies have shown promising results with similar antifungal treatments in animal models, indicating potential for success in human applications.
Where this research is happening
Cincinnati, United States
- Cincinnati VA Medical Center Research — Cincinnati, United States (Active)
Researchers
- Principal investigator: Cushion, Melanie T — Cincinnati VA Medical Center Research
- Study coordinator: Cushion, Melanie T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.