Using probenecid to treat heart failure in veterans
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
This study is looking at whether a safe medication called probenecid can help improve heart function in veterans with heart failure, making their hearts work better and feel stronger.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati VA Medical Center Research NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11044133 on NIH RePORTER |
What this research studies
This research investigates the use of probenecid, a safe and commonly used medication, to improve heart function in veterans suffering from heart failure with reduced ejection fraction (HFrEF). The study focuses on how probenecid acts on specific receptors in heart cells to enhance calcium handling and contractility, potentially leading to better heart performance. By building on previous laboratory findings and a small pilot study, this research aims to provide a new treatment option for veterans with this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans aged 21 and older who have been diagnosed with heart failure with reduced ejection fraction.
Not a fit: Patients who do not have heart failure or those with other types of heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a novel and effective treatment for veterans with heart failure, improving their quality of life and survival rates.
How similar studies have performed: Previous studies have shown promising results with similar approaches, particularly in small pilot studies, indicating potential for further exploration.
Where this research is happening
Cincinnati, United States
- Cincinnati VA Medical Center Research — Cincinnati, United States (Active)
Researchers
- Principal investigator: Rubinstein, Jack — Cincinnati VA Medical Center Research
- Study coordinator: Rubinstein, Jack
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.