Understanding how STAT3 affects NK cell function in different contexts
Official title: Investigating the molecular basis of context-dependent STAT3 function in NK cells
Funded at Sloan-Kettering Inst Can Research · NIH-10985381 · Data updated 2026-11-12
This study is looking at how a protein called STAT3 helps natural killer (NK) cells, which are important for fighting off viruses, and it aims to understand how different signals affect this protein's role, so we can learn more about how our immune system works and how it might help in treating cancer and viral infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $114,722 |
| NIH project number | 1K99AI180360-01A1 |
| Project ID | NIH-10985381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with viral infections or cancers where NK cell function is critical.
✕Less likely to help
Patients with conditions unrelated to NK cell function or those not experiencing viral infections or cancers may not benefit from this research.
What this research studies
This research investigates the role of the STAT3 protein in Natural Killer (NK) cells, which are essential for fighting viral infections. The study aims to determine how various signals influence STAT3's function, particularly in different infection scenarios. By examining how STAT3 affects NK cell growth and activity, the research seeks to uncover important mechanisms that could enhance our understanding of immune responses and cancer biology. Patients may benefit from insights gained about NK cell function in viral infections and cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses against viral infections and cancer.
How similar studies have gone: Previous research has shown that understanding the molecular mechanisms of immune cells can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Grassmann, Simon — Sloan-Kettering Inst Can Research
- Study coordinator: Grassmann, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.