Understanding how Speg proteins affect muscle function
Official title: Identification of Speg Binding Proteins and Phosphorylation Targets in Skeletal and Cardiac Muscle
Funded at Baylor College of Medicine · NIH-10645535 · Data updated 2026-11-12
This study is looking at how a protein called Speg affects our muscles, especially when there's not enough of it, which can lead to serious muscle problems like centronuclear myopathy and dilated cardiomyopathy; by using special mice, the researchers hope to learn more about how Speg works and what might help improve muscle health for people with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $387,200 |
| NIH project number | 1R21AR082613-01 |
| Project ID | NIH-10645535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with centronuclear myopathy or dilated cardiomyopathy.
✕Less likely to help
Patients with muscle conditions unrelated to Speg deficiency may not benefit from this research.
What this research studies
This research investigates the role of Speg proteins in skeletal and cardiac muscles, particularly how their deficiency can lead to severe muscle diseases like centronuclear myopathy and dilated cardiomyopathy. By using specially designed mice, the researchers aim to identify the proteins that interact with Speg and the specific phosphorylation targets that are affected by Speg deficiency. Advanced techniques such as mass spectrometry will be employed to analyze these interactions and their implications for muscle health. The findings could provide insights into the underlying mechanisms of muscle-related diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for severe muscle diseases, improving outcomes for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding protein interactions in muscle diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lee, Chang Seok — Baylor College of Medicine
- Study coordinator: Lee, Chang Seok
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.