Understanding how specific genes affect brain development and disorders
The role of the protocadherin gene cluster in neurodevelopment and the implications for neurodevelopmental disorders
This study is looking at how certain genes help brain cells, or neurons, figure out their own identities and stay in their own spaces, which is important for healthy brain development, and it could help us understand conditions like autism better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10920484 on NIH RePORTER |
What this research studies
This research investigates the role of protocadherin genes in the development of neurons, focusing on how these genes help neurons identify themselves and avoid overlapping with each other. By studying the interactions of these genes at the cellular level, researchers aim to uncover the mechanisms that lead to proper neuronal wiring and behavior. The approach includes using cellular assays and biophysical methods to analyze how these proteins function and signal within the brain. The findings could provide insights into neurodevelopmental disorders like autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those diagnosed with autism spectrum disorder.
Not a fit: Patients with neurodevelopmental disorders not related to the protocadherin gene cluster may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar genetic factors in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Flaherty, Erin — Columbia University Health Sciences
- Study coordinator: Flaherty, Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.