Understanding how single stranded DNA mutations occur
Official title: Determining the factors that impact single stranded DNA mutagenesis
Funded at Medical University of South Carolina · NIH-11087657 · Data updated 2026-11-12
This study is looking at how certain proteins and enzymes help fix damaged single-stranded DNA, which can lead to mutations linked to cancer, using yeast and human cells to better understand these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $377,500 |
| NIH project number | 5R35GM151021-03 |
| Project ID | NIH-11087657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit specific mutation patterns linked to ssDNA damage.
✕Less likely to help
Patients with cancers not associated with ssDNA mutations or those without a genetic predisposition to such mutations may not benefit from this research.
What this research studies
This research investigates the factors that influence mutations in single stranded DNA (ssDNA), which is particularly susceptible to damage. By examining the roles of specific proteins and enzymes involved in DNA repair and damage response, the study aims to uncover the mechanisms that lead to mutation patterns associated with cancers. The research employs advanced techniques, including yeast models and human cell cultures, alongside bioinformatics tools to analyze large datasets and sequencing information. This comprehensive approach seeks to enhance our understanding of how ssDNA mutagenesis occurs and how it can be influenced.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers associated with ssDNA mutations.
How similar studies have gone: Previous studies have shown success in understanding DNA damage and repair mechanisms, suggesting that this research could build on established knowledge in the field.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Saini, Natalie — Medical University of South Carolina
- Study coordinator: Saini, Natalie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.