Understanding how single stranded DNA mutations occur
Determining the factors that impact single stranded DNA mutagenesis
This study is looking at how certain proteins and enzymes help fix damaged single-stranded DNA, which can lead to mutations linked to cancer, using yeast and human cells to better understand these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11087657 on NIH RePORTER |
What this research studies
This research investigates the factors that influence mutations in single stranded DNA (ssDNA), which is particularly susceptible to damage. By examining the roles of specific proteins and enzymes involved in DNA repair and damage response, the study aims to uncover the mechanisms that lead to mutation patterns associated with cancers. The research employs advanced techniques, including yeast models and human cell cultures, alongside bioinformatics tools to analyze large datasets and sequencing information. This comprehensive approach seeks to enhance our understanding of how ssDNA mutagenesis occurs and how it can be influenced.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that exhibit specific mutation patterns linked to ssDNA damage.
Not a fit: Patients with cancers not associated with ssDNA mutations or those without a genetic predisposition to such mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers associated with ssDNA mutations.
How similar studies have performed: Previous studies have shown success in understanding DNA damage and repair mechanisms, suggesting that this research could build on established knowledge in the field.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Saini, Natalie — Medical University of South Carolina
- Study coordinator: Saini, Natalie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.