Understanding how sex differences affect heart tissue remodeling
Official title: Decoupling sex chromosome and sex hormone regulation of cardiac myofibroblast activation
Funded at University of California, San Diego · NIH-10998141 · Data updated 2026-11-12
This study is looking at how men and women's hearts react differently to heart failure, focusing on the impact of their unique genes and hormones, to help create better treatments that work for each gender.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,132 |
| NIH project number | 1F31HL176153-01 |
| Project ID | NIH-10998141 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure, particularly those interested in understanding the sex-specific aspects of their condition.
✕Less likely to help
Patients who do not have heart failure or those with conditions unrelated to cardiac health may not benefit from this research.
What this research studies
This research investigates how male and female hearts respond differently to heart failure, focusing on the role of sex chromosomes and hormones in cardiac tissue remodeling. By using animal models and advanced cell culture techniques, the study aims to separate the effects of sex chromosomes from those of sex hormones on heart tissue. This approach will help clarify why men and women experience heart failure differently, potentially leading to more effective, tailored treatments for each sex.
Why it matters
Potential benefit: If successful, this research could lead to sex-specific therapies that improve heart failure outcomes for both men and women.
How similar studies have gone: Previous research has shown promising results in understanding sex differences in cardiac health, but this specific approach to decoupling sex chromosomes and hormones is relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Gorashi, Rayyan — University of California, San Diego
- Study coordinator: Gorashi, Rayyan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.