Understanding how SARS-CoV-2 interacts with human cells
Official title: Translational Regulation of SARS-CoV-2 in response to viral S protein-induced signaling
Funded at Cleveland State University · NIH-10906983 · Data updated 2026-11-12
This study is looking at how the COVID-19 virus interacts with our lung cells, specifically focusing on a part of the virus's RNA that helps it make proteins when it enters our body, and it aims to find out more about how this affects inflammation in people with COVID-19.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 14, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $185,625 |
| NIH project number | 5R21AI173187-02 |
| Project ID | NIH-10906983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been infected with SARS-CoV-2 or are at risk of COVID-19 infection.
✕Less likely to help
Patients who are not affected by COVID-19 or those with unrelated respiratory conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the SARS-CoV-2 virus interacts with human lung cells, focusing on a specific RNA element that regulates viral protein translation in response to the virus's spike protein. By studying how this RNA element senses signals from host cells, the research aims to uncover new insights into the virus's behavior and its impact on inflammation. The approach involves biochemical techniques to analyze the binding of viral and host proteins to RNA elements, which could lead to a better understanding of COVID-19 pathology.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing COVID-19 and related respiratory infections.
How similar studies have gone: Previous studies have shown success in understanding host-virus interactions in other respiratory pathogens, indicating potential for this approach.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Mazumder, Barsanjit — Cleveland State University
- Study coordinator: Mazumder, Barsanjit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.