Understanding how SAM gene mutations affect cell processes and genome stability
Characterization of SAM gene mutation impacts on cellular processes and genome instability
This study is looking at how changes in certain genes can affect cell health and stability, which might help us understand cancer better and improve treatment options for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Kentucky University NIH-funded |
| Lab location | 1 site (Highland Heights, United States) |
| Project ID | NIH-10874266 on NIH RePORTER |
What this research studies
This research investigates the effects of mutations in the SAM genes on cellular functions and genome stability, particularly focusing on how these mutations influence the methyl cycle and the biosynthesis of AdoMet. By studying yeast and human gene counterparts, the research aims to uncover the mechanisms by which changes in gene dosage affect cellular processes and contribute to cancer. Patients may benefit from insights gained about how these genetic alterations impact their health and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known mutations in the SAM genes or those with related cancer diagnoses.
Not a fit: Patients without SAM gene mutations or those not affected by related cellular processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for cancers associated with SAM gene mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of gene mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Highland Heights, United States
- Northern Kentucky University — Highland Heights, United States (Active)
Researchers
- Principal investigator: Strome, Erin D — Northern Kentucky University
- Study coordinator: Strome, Erin D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.