Understanding how SAM gene mutations affect cell processes and genome stability
Official title: Characterization of SAM gene mutation impacts on cellular processes and genome instability
Funded at Northern Kentucky University · NIH-10874266 · Data updated 2026-11-12
This study is looking at how changes in certain genes can affect cell health and stability, which might help us understand cancer better and improve treatment options for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Kentucky University NIH-funded |
| Lab location | 1 site (Highland Heights, United States) |
| Project start | March 1, 2020 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $420,000 |
| NIH project number | 2R15GM132818-02 |
| Project ID | NIH-10874266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known mutations in the SAM genes or those with related cancer diagnoses.
✕Less likely to help
Patients without SAM gene mutations or those not affected by related cellular processes may not benefit from this research.
What this research studies
This research investigates the effects of mutations in the SAM genes on cellular functions and genome stability, particularly focusing on how these mutations influence the methyl cycle and the biosynthesis of AdoMet. By studying yeast and human gene counterparts, the research aims to uncover the mechanisms by which changes in gene dosage affect cellular processes and contribute to cancer. Patients may benefit from insights gained about how these genetic alterations impact their health and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for cancers associated with SAM gene mutations.
How similar studies have gone: Previous research has shown promising results in understanding the role of gene mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northern Kentucky University
Highland Heights, United States Active
Researchers
- Principal investigator: Strome, Erin D — Northern Kentucky University
- Study coordinator: Strome, Erin D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.