Investigating how genetics influence brain development affected by environmental toxins.
Official title: Genetic Susceptibility to Developmental Benzo[a]pyrene Neurotoxicity
Funded at Northern Kentucky University · NIH-10730699 · Data updated 2026-11-12
This study is looking at how our genes might make some people more sensitive to a harmful chemical called benzo[a]pyrene, which can come from pollution and certain foods, and how this exposure during important growth stages could lead to lasting brain and behavior problems, with the hope of finding ways to protect against these issues for those at risk.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern Kentucky University NIH-funded |
| Lab location | 1 site (Highland Heights, United States) |
| Project start | May 16, 2019 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $420,000 |
| NIH project number | 2R15ES030541-02A1 |
| Project ID | NIH-10730699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include children and adolescents who have been exposed to environmental pollutants, particularly those with a family history of neurodevelopmental disorders.
✕Less likely to help
Patients who have not been exposed to environmental toxins or who do not have genetic variations related to the study may not receive benefit from this research.
What this research studies
This research focuses on understanding how genetic differences affect the brain's vulnerability to neurotoxicity caused by benzo[a]pyrene (BaP), a harmful chemical found in pollution and certain foods. By studying both human genetic variations and animal models, the research aims to uncover how exposure to BaP during critical developmental periods can lead to long-lasting cognitive and behavioral issues. The approach involves examining specific genes that may influence the brain's response to these environmental toxins, providing insights into potential protective factors or risks. Patients may benefit from findings that could lead to better understanding and prevention of neurodevelopmental disorders linked to environmental exposures.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive and behavioral issues in children exposed to environmental toxins.
How similar studies have gone: Previous studies have shown success in understanding the impact of genetic factors on neurotoxicity, suggesting that this research builds on established findings.
Where this research is happening
-
Northern Kentucky University
Highland Heights, United States Active
Researchers
- Principal investigator: Curran, Christine Perdan — Northern Kentucky University
- Study coordinator: Curran, Christine Perdan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.