Understanding how PTSD affects bone healing in Veterans
Official title: BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Impacts of PTSD on Fracture Healing
Funded at Ralph H Johnson VA Medical Center · NIH-10920612 · Data updated 2026-11-12
This study is looking at how PTSD affects the healing of broken bones in older Veterans, and it aims to find new ways to help them recover better and prevent bone loss.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ralph H Johnson VA Medical Center NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX005870-01A1 |
| Project ID | NIH-10920612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging Veterans who have experienced fractures and may also be dealing with PTSD.
✕Less likely to help
Patients who do not have a history of fractures or PTSD may not receive benefits from this research.
What this research studies
This research investigates the impact of PTSD on the healing process of bone fractures in aging Veterans. By utilizing pre-clinical models, the study aims to explore new therapeutic strategies that enhance bone regeneration and prevent osteoporosis, which is a significant concern for this population. The collaborative effort involves various VA investigators who will analyze the effects of parathyroid hormone (PTH) on bone health and assess how health issues unique to Veterans influence bone repair. The goal is to develop innovative approaches that improve recovery outcomes for Veterans suffering from fractures.
Why it matters
Potential benefit: If successful, this research could lead to improved healing and recovery from bone fractures for Veterans, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between PTSD and physical health outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ralph H Johnson VA Medical Center
Charleston, United States Active
Researchers
- Principal investigator: Larue, Amanda C. — Ralph H Johnson VA Medical Center
- Study coordinator: Larue, Amanda C.
Related research
Other NIH-funded projects on the same topics.
-
How PTSD and related health problems affect bone healing in Veterans
This project looks at whether conditions like PTSD make bones heal more slowly in aging Veterans and whether boosting the bone-building effects of parathyroid hormone can help them recover faster.
-
Understanding how PTSD affects self-control and brain function
Researchers are studying how PTSD changes the brain’s control over thoughts and actions, and how this might affect Veterans’ daily lives and responses to treatment.
-
Ketamine to boost fear extinction and memory on PTSD patients
A study testing whether ketamine can help people with PTSD better relearn and forget fear when given in a guided treatment plan.
-
Adenosine-based help to speed up bone fracture healing in older adults
A biomaterial-based approach delivers adenosine locally to fractures to speed healing in aging bones.
-
Treating PTSD and opioid use disorder in residential care with Written Exposure Therapy (WEST)
A short, patient-friendly plan to adapt a proven PTSD therapy for people with opioid use disorder in residential treatment and test its practicality and impact.
-
Dynamic PTSD-Related Cognitive Risk in Aging WTC Responders
This project follows World Trade Center responders as they age to understand how PTSD symptoms relate to changes in thinking skills over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.