Understanding how proteins are sorted in cells lacking a specific adaptor protein.
Official title: Mechanisms of polarized protein sorting in AP-1B-deficient epithelia
Funded at Wayne State University · NIH-10894292 · Data updated 2026-11-12
This study is looking at how cells in our body sort important proteins to the right places, especially when a key helper protein is missing, and it aims to find other ways these cells can still do their job, which could help us understand and treat diseases that affect these cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $385,000 |
| NIH project number | 5R35GM150570-02 |
| Project ID | NIH-10894292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting epithelial tissues, such as kidney or retinal disorders.
✕Less likely to help
Patients with non-epithelial related conditions are unlikely to benefit from this research.
What this research studies
This research investigates the mechanisms by which epithelial cells sort proteins to their appropriate locations within the cell, particularly in cases where a key adaptor protein, AP-1B, is absent. The study focuses on how these sorting processes occur in endosomal compartments and aims to identify alternative pathways that may compensate for the lack of AP-1B in certain epithelial tissues. By exploring these mechanisms, the research seeks to uncover insights that could lead to better understanding and treatment of diseases affecting epithelial function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to epithelial dysfunction.
How similar studies have gone: Previous research has shown success in understanding protein sorting mechanisms, but this specific approach is exploring novel pathways that have not been extensively tested.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Caceres, Paulo Sebastian — Wayne State University
- Study coordinator: Caceres, Paulo Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.